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Search the history of over billion web pages on the Internet. John Motley Morehead, I am going to try to tell something about the man as his adopted "nephews" saw him. The most striking quality of Mr. Morehead's was his ever abundant humor. When addressing the scholars every Octo- ber, his stories and puns would bring resounding laughter which, if one thought about it long enough, could probably still be heard ringing from the marble columns and panelled walls of the beautiful Morehead Planetarium dining room.
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Interferons IFNs are class II cytokines that are key components of the innate immune response to virus infection. Prolonged treatment is associated with more serious adverse events including leucopenia, thrombocytopenia, increased hepatic transaminases, and neuropsychiatric effects. Systemic administration of type I IFN results in activation of IFN receptors present on essentially all types of nucleated cells, including neurons and hematopoietic stem cells, in addition to target cells. This may well explain the wide spectrum of IFN associated toxicities. Recent reports suggest that certain polymorphisms in type I IFN signaling molecules are associated with IFN-induced neutropenia and thrombocytopenia in patients with chronic hepatitis C. Repeated administration of recombinant IFNs can cause in a break in immune tolerance to self-antigens in some patients resulting in the production of neutralizing antibodies NABs to the recombinant protein homologue. Appearance of NABs is associated with reduced pharmacokinetics, pharmacodynamics, and a reduced clinical response.
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Safety, Tolerability, and Immunogenicity of Interferons

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